Symposium

Second International NUT Carcinoma Research Symposium

Thursday, November 5, 2026
8:00am to 6:00pm
The Yawkey Center for Cancer Care
3RD FLOOR CONVENTION CENTER
450 Brookline Avenue
Boston, MA 02215
(Virtual Attendance Available)
Click HERE to register
*Registration for in-person attendance closes on Oct 23
*Registration for virtual attendance closes on Oct 30

Join Dana-Farber Cancer Institute for the 2nd International NUT Carcinoma Research Symposium, a timely meeting of clinical and translational oncology leaders. Sponsored by the NUT Carcinoma Alliance, this symposium aims to share critical research updates, develop consensus treatment guidelines, and set the national agenda for clinical trials, positioning NUT carcinoma research for its next breakthrough moment.


SYMPOSIUM AGENDA
(Subject to Change)

8:00 AM. Breakfast and Registration

8:30 AM. Introductory Presentations
Welcome and Introduction
Jia Luo, MD, Dana-Farber Cancer Institute (DFCI)
 Christopher A. French, MD, Brigham and Women’s Hospital (BWH)
 Geoffrey Shapiro, MD, PhD, DFCI

  • Introduction to NUT Carcinoma: Background and Science – Christopher A. French, MD, BWH
  • Patient Perspective and Interview – Maddie Woepse, The Patrick Woepse Foundation
  • NUT Carcinoma Registry Update: Informing Clinical Care and Translational Research – Jia Luo, MD, DFCI
  • Next Generation Diagnostics in NC Diagnosis – John Iafrate, MD, PhD, MGH

9:35 AM. Break

9:45 AM. Developing NUT Carcinoma Treatment Guidelines (Panel Discussion)
Chairs: Jia Luo, MD, DFCI; Steven Dubois, MD, MS, DFCI; Benjamin H. Kann, MD, BWH; Hassan A. Khalil, MD, BWH

  • Thoracic Medical Oncology – Jia Luo, MD, DFCI; and Robert Hsu, MD, Keck School of Medicine at USC
  • Head and Neck Oncology – Michael Dennis, MD, DFCI
  • Pediatrics – Steven Dubois, MD, MS, DFCI and Boston Children’s Hospital; and Michael V. Ortiz, MD, MSKCC
  • Pathology – Lynette M. Sholl, MD, DFCI
  • Thoracic Surgery – Hassan A. Khalil, MD, BWH
  • ENT Surgery – Rosh K. Sethi, MD, MPH, DFCI
  • Thoracic Radiation Oncology – Benjamin H. Kann, MD, BWH
  • Immunology and Therapeutics – Sarina A. Piha-Paul, MD Anderson Cancer Center at the University of Texas (MDACC)
  • ENT Radiation Oncology – Roy Tishler, DFCI
  • Nursing Professionals – Stephanie Canty, CNP, DFCI and Samantha Janell, BSN, RN, DFCI

11:15 AM. Future Directions Part One
Chair: Kyle P. Eagen, PhD, Baylor College of Medicine

  • GENOME ORIGAMI: DNA Misfolding in NUT Carcinoma – Kyle P. Eagen, PhD, Baylor College of Medicine
  • BD2-selective inhibition is a unique vulnerability in NUT carcinoma – Christopher A. French, MD, BWH
  • Exploiting replicative stress in NUT carcinoma with ATR inhibition – Daryl Griffin, Laboratory of Geoffrey Shapiro, MD, PhD, DFCI
  • Transcriptional Chemical Inducers of Proximity (TCIPs) in NUT carcinoma – Hayden Malone, PhD, Laboratory of Jerry
    Crabtree, Stanford University

1:00 PM Lunch and Keynote Address
Keynote Speaker: George Demetri, DFCI
Introduced by Geoffrey Shapiro, MD, PhD, DFCI

2:00 PM. Future Directions Part Two
Chair: Hassan A. Khalil, MD, BWH

  • Tumor Microenvironment (TME) – James Brenner, DFCI
  • Immune Therapy/Cancer Vaccination – Derin Keskin, DFCI
  • PRAME and Other NC Epitopes – Alex Rubinsteyn, PhD, UNC School of Medicine
  • Antibody Drug Conjugates – Juyoung Choi, The Choi Lab at Samsung Advanced Institute for Health Sciences & Technology (SAIHST), Sungkyunkwan University; Laboratory of Molecular and Digital Pathology for Theranostics

3:40 PM. Break

3:45 PM. Setting the Clinical Trials Agenda for NUT Carcinoma (Panel Discussion)
Chairs: Michael Dennis, MD, DFCI; Geoffrey Shapiro, MD, PhD, DFCI
Lorraine Pelosof, MD, PhD, National Cancer Institute
Jia Luo, MD, DFCI
Geoffrey Shapiro, MD, PhD, DFCI
Sarina A. Piha-Paul, MDACC
Jochen Lorch, MD, Northwestern Medicine
Kartik Sehgal, MD, DFCI

4:45 PM. Closing Remarks
Geoffrey Shapiro, MD, PhD, DFCI
 Skip Victor, Patient Advocate

5:00 PM. Reception and Networking

6:00 PM. End of Day

This event is sponsored by the NUT Carcinoma Alliance.